Healing diabetic foot ulcers

With Cell Research Corp, GCGH is studying better ways to treat diabetic foot ulcers, one of the most common reasons people with diabetes lose a limb.

GCGH clinician and volunteer treating a patient

Why this matters

Diabetic foot ulcers are open wounds on the feet of people with diabetes. High blood sugar, poor blood flow, nerve damage and foot deformities all raise the risk. Without good care, an ulcer can lead to amputation.

What we are doing

All patients are treated under our Sollagen Protocol:

1. DebridementRemoving dead tissue
2. Infection controlTreating and preventing infection
3. OffloadingTaking pressure off the wound
4. Advanced dressingsSpecialist wound dressings
5. Follow-upUntil the wound has closed

Case study: one patient's healing

Patient CRC 016, a 48-year-old woman with diabetes for 8 years, controlled on tablets. Her foot ulcer had not healed for 72 days. At the start it measured 35 × 25 mm, with a red, wet base and no infection. Dr Enock Cohen Kabuye treated her under the Sollagen Protocol from 18 October 2022.

72 daysunhealed before treatment
28 daysto full closure
7recorded visits
VisitDate (2022)Size (mm)Area change*
TV118 Oct · Start35 × 25Start
TV221 Oct · Day 325 × 25−29%
TV325 Oct · Day 730 × 19−35%
TV428 Oct · Day 1020 × 18−59%
TV51 Nov · Day 1412 × 12−84%
TV64 Nov · Day 1717 × 10−81%
TV715 Nov · Day 28Healed−100%

*Approximate, from length × width. At visit TV6 the wound was briefly a little larger than at TV5, as recorded.

Show wound photos (7)Clinical images of an open foot ulcer
Patient CRC 016 ulcer at visit TV1, start
TV1 · Start · 35 × 25 mm
Patient CRC 016 ulcer at visit TV2, day 3
TV2 · Day 3 · 25 × 25 mm
Patient CRC 016 ulcer at visit TV3, day 7
TV3 · Day 7 · 30 × 19 mm
Patient CRC 016 ulcer at visit TV4, day 10
TV4 · Day 10 · 20 × 18 mm
Patient CRC 016 ulcer at visit TV5, day 14
TV5 · Day 14 · 12 × 12 mm
Patient CRC 016 ulcer at visit TV6, day 17
TV6 · Day 17 · 17 × 10 mm
Patient CRC 016 ulcer at visit TV7, day 28
TV7 · Day 28 · Healed

Please note: this is a single case. Results vary between patients: some heal quickly, some more slowly, and some do not improve. Published with the patient's consent; she is identified only by her study code.

How the research is governed

Every item below links to the document itself, so anyone can check it.

PartnerCell Research Corp.
Patient consentEvery participant gives written informed consent.
Galilee Medicare initiatives

Our programmes and initiatives

Proposed by our Director, Adam Hirschfield, these programmes take GCGH beyond everyday care: finding better treatments, preventing disease and training the next generation of health workers.

Two children at GCGH sharing a secret

Research programme

GCGH keeps detailed records of the patients it treats. With ethics approval, we use anonymised records to learn which treatments work best, as we grow from a general hospital into one that also carries out research.

Medicines and partnerships

With local and international partners, we look for better ways to diagnose and treat disease. Our diabetic foot ulcer study with Cell Research Corp is the first of these partnerships.

About the study

Outbreak and epidemic control

We help respond to outbreaks of infectious diseases such as Ebola, cholera and measles, and to the long-running HIV and tuberculosis epidemics, and we collect the data needed to prevent and treat them better.

Clinical research

Research to reduce avoidable illness and deaths from long-term conditions, and to improve health for people living with HIV, diabetes and high blood pressure.

HIV care at GCGH

Training

We train our own staff and welcome students from Uganda and abroad. Continuous learning keeps our care safe and up to date.

Training, jobs and volunteering

Pregnancy and maternal health

Started in 2014 because of high rates of complications and deaths in pregnancy. We collect data to prevent avoidable maternal deaths, with extra support for very young mothers, older mothers and women with disabilities.

Maternity care
Sharing our work · London, May 2022

GCGH at the Royal College of Physicians

In May 2022, our Director Adam Hirschfield joined Dr Flor Kent at Wigmore Medical Presents, an aesthetic medicine conference held at the Royal College of Physicians in London. Dr Kent gave a talk, The Sculptor as an Aesthetic Doctor, and the #MedicalHelpforUganda table introduced GCGH and its patients to doctors and clinics from the UK and abroad.

During the conference Adam met Nicholas Lang and Dr Ivor Lim of Calecim, from Cell Research Corp in Singapore, our research partner on diabetic foot ulcers. He also met Dr Jamshed JJ Masani and David Hicks, chairman of Wigmore Medical. Meetings like these open the door to the partners, expertise and support that our research and our patients depend on.

Adam Hirschfield and Dr Flor Kent with supporters at the #MedicalHelpforUganda table
At the #MedicalHelpforUganda table.
Dr Flor Kent presenting The Sculptor as an Aesthetic Doctor at the Royal College of Physicians
Dr Kent's talk, The Sculptor as an Aesthetic Doctor.
Adam Hirschfield, Dr Flor Kent and David Hicks at the conference
With David Hicks, chairman of Wigmore Medical.
Read about #MedicalHelpforUganda and our supporters →
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